Cannabis Human Genetic Panel

Do you know how your body reacts to Marijuana compared to other people? The use of cannabis is increasing all over the world. It is useful to know how your body is going to react to regular cannabis use. This genetic test offers information to help make better decisions regarding the use of cannabis.

Genetic test could tell you if you are at higher risk for a bad reaction to Cannabinoids (active chemical ingredients in Marijuana, from the Cannabis plant), and how profoundly Cannabis will alter your ability to metabolize other drugs or medications. The relationship between our genes and how it affects our body's response to Marijuana is being actively studied by scientists throughout the world. Currently, there are a few genes that are associated with Cannabinoid metabolism, side effects, or addiction risk.

If you've smoked Marijuana before and you would like to learn more - The name Cannabis is derived from the Cannabis plants (Cannabis Sativa species), of which HEMP is one of the most common. Cannabis plants grow wild in many of the tropical and temperate areas of the world. HEMP plant grows very fast, and can be cultivated for industrial uses. Cannabis plants contain hundreds of chemical compounds. One group of compounds are Terpenes, most known for giving cannabis a variety of distinctive scents and flavors. Another compound, Cannabinoids, is what is known for creating medicinal and recreational psychotropic effects.

In Cannabis or Marijuana plants, there are over 100 known Cannabinoids (active psychotropic ingredients). Two of the most commonly known Canniboids are Cannabidiol (CBD) and Tetrahydrocannabinol (THC).

CBD provides many of the medical benefits that have justified legalizing Cannabis use. THC is the psychoactive component that gets you high - though it may have medicinal benefits as well.

There are two main uses for cannabis, medicinal and recreational use.

Medicinal use includes pain management, anxiety, stress and/or sleep disorders.

Many substances interact with one another while inside the body. Knowing how you metabolize each substance combined with the use of cannabis can help avoid any dangerous interactions. Also, while taking medications it is important to know the side effects this will have in the future. Knowing your predisposition to some drugs could save your life.

Same test could tell you if you’re at higher risk to develop a habitual dependence to other drugs

There is a test that can identify genetic “markers” in your DNA that could indicate a higher probability toward adverse reactions from cannabis use and/or the risk of becoming dependent on cannabis or other drugs. Genetic markers are identified by what geneticists call “polymorphisms” in a gene. Although genes always have specific locations on the DNA, regardless of the individual, the exact makeup of that gene may differ from person to person.

The genes tested are divided into two groups: Metabolism and Dependency.

  1. One group is the drug metabolizing group.
    • The drug metabolizing genes control how quickly drugs (including cannabinoids, THC, and CBD) are metabolized in the body.
    • A person could be a rapid metabolizer if a regular dose has little to no effect. On the other hand, for a poor metabolizer a regular dose can have a toxic effect on their body since it isn’t broken down properly.
    • The genetic polymorphisms can predict how the body will metabolize drugs. With this information, you and your doctor can make better treatment decisions to reach an effective and safe dosage schedule in a shorter time, requiring fewer visits to the doctor.
  2. The other group is related to genes associated with drug dependency.
    • Roughly 10 percent of cannabis users will develop a dependence on cannabis.
    • Polymorphisms in this gene increase your chance of becoming addicted to cannabis.

A person who carries polymorphisms in both dependency and metabolizing genes is at most risk for undesired effects. For example, a person who is a CYP2C9 poor metabolizer is at higher risk for experiencing an overdose response even with recommended dosage. A person who has altered metabolism due to variations in the CYP2D6 or CYP2C19 genes is at higher risk for drug/drug interactions, side effects, or adverse events. Those who have the dependency polymorphism may be at higher risk for cannabis addiction or dependency.**

Cannabis panel includes detection of genetic polymorphisms in CYP450 or other metabolizing enzymes such as:

  • CYP2D6
  • CYP2C19
  • CYP2C9
  • CYP3A4
  • FAAH

The use of cannabis is increasing all over the world. It is useful to know how your body is going to react to regular cannabis use. This genetic test offers information to help make better decisions regarding the use of cannabis.

Contact us to receive a kit and take the test.

For the same price, there will be a free 5-minute phone consultation to review results with a qualified person.

FirmaLab offers a Cannabis Genetic Panel to test for the following variations:

Cannabis Genetic Panel
Gene and Variation Effect Caused
CYP2C9*2 Poor metabolizer
CYP2C9*3 Poor metabolizer
CYP2D6*4 Poor metabolizer
CYP3A4*2 Poor metabolizer
CYP3A4*11 Poor metabolizer
CYP3A4*12 Poor metabolizer
CYP3A4*17 Poor metabolizer
FAAH rs324420 Cannabis dependency
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